I have one big issue to pick at
People who compare this to other roguelikes, you need to realise that nethack and crawl weren't made by one or two people in flash. This is a great game for what it is as long as you don't expect it to be something it's not.
Al this being said I took issue with automatic replacement and item selling in the inventory, I didn't feel in control of my character. I wasn't able to make many decisions whether good or bad, and for me that is a vital part of any roguelike.
I did however love everything about the user interface.
Also to that one guy who complained about not having a save feature, harden up, go play some slashem and then tell me how unfair this game is.